Severity: 8192
Message: Creation of dynamic property CI_URI::$config is deprecated
Filename: core/URI.php
Line Number: 101
Severity: 8192
Message: Creation of dynamic property CI_Router::$uri is deprecated
Filename: core/Router.php
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Severity: 8192
Message: Creation of dynamic property Welcome::$benchmark is deprecated
Filename: core/Controller.php
Line Number: 75
Severity: 8192
Message: Creation of dynamic property Welcome::$hooks is deprecated
Filename: core/Controller.php
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Message: Creation of dynamic property Welcome::$config is deprecated
Filename: core/Controller.php
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Message: Creation of dynamic property Welcome::$log is deprecated
Filename: core/Controller.php
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Severity: 8192
Message: Creation of dynamic property Welcome::$utf8 is deprecated
Filename: core/Controller.php
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Message: Creation of dynamic property Welcome::$uri is deprecated
Filename: core/Controller.php
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Message: Creation of dynamic property Welcome::$exceptions is deprecated
Filename: core/Controller.php
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Message: Creation of dynamic property Welcome::$router is deprecated
Filename: core/Controller.php
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Message: Creation of dynamic property Welcome::$output is deprecated
Filename: core/Controller.php
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Message: Creation of dynamic property Welcome::$security is deprecated
Filename: core/Controller.php
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Message: Creation of dynamic property Welcome::$input is deprecated
Filename: core/Controller.php
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Message: Creation of dynamic property Welcome::$lang is deprecated
Filename: core/Controller.php
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Message: Creation of dynamic property Welcome::$load is deprecated
Filename: core/Controller.php
Line Number: 78
Severity: 8192
Message: Creation of dynamic property Welcome::$db is deprecated
Filename: core/Loader.php
Line Number: 390
Severity: 8192
Message: Creation of dynamic property CI_DB_mysqli_driver::$failover is deprecated
Filename: database/DB_driver.php
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Severity: 8192
Message: Creation of dynamic property Welcome::$form_validation is deprecated
Filename: core/Loader.php
Line Number: 1290
Severity: 8192
Message: Return type of CI_Session_files_driver::open($save_path, $name) should either be compatible with SessionHandlerInterface::open(string $path, string $name): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 132
Severity: 8192
Message: Return type of CI_Session_files_driver::close() should either be compatible with SessionHandlerInterface::close(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 290
Severity: 8192
Message: Return type of CI_Session_files_driver::read($session_id) should either be compatible with SessionHandlerInterface::read(string $id): string|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 164
Severity: 8192
Message: Return type of CI_Session_files_driver::write($session_id, $session_data) should either be compatible with SessionHandlerInterface::write(string $id, string $data): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 233
Severity: 8192
Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 313
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Message: Return type of CI_Session_files_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 354
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
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Severity: Warning
Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent
Filename: Session/Session.php
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Filename: Session/Session.php
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Filename: Session/Session.php
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Filename: Session/Session.php
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Filename: Session/Session.php
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Filename: Session/Session.php
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Severity: Warning
Message: session_start(): Session cannot be started after headers have already been sent
Filename: Session/Session.php
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Message: Creation of dynamic property Welcome::$session is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property Welcome::$curl is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property Welcome::$Reports_model is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property Welcome::$User_model is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property Welcome::$data is deprecated
Filename: controllers/Welcome.php
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Filename: core/Loader.php
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Message: Creation of dynamic property CI_Loader::$benchmark is deprecated
Filename: core/Loader.php
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Filename: core/Loader.php
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Filename: core/Loader.php
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Filename: core/Loader.php
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Filename: core/Loader.php
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Filename: core/Loader.php
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Message: Creation of dynamic property CI_Loader::$curl is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property CI_Loader::$Reports_model is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property CI_Loader::$User_model is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property CI_Loader::$data is deprecated
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Published : 30 Oct 2020
Drug Name: NI-0101
Biopharma firm Edesa Biotech has received clearance from the US Food and Drug Administration (FDA) to initiate the Phase II part of Phase II/III clinical trial of its investigational drug EB05 to treat hospitalized patients with Covid-19.
Edesa has started the site initiation process at hospitals in the US.
Earlier, Health Canada had approved the Phase II/III study protocol.
The experimental monoclonal antibody, EB05 has the potential to regulate the overactive immune response associated with Acute Respiratory Distress Syndrome (ARDS), the main cause of death in Covid-19 patients.
EB05 hinders toll-like receptor 4 (TLR4) signaling, which is a key mediator of inflammation that is responsible for acute lung injury triggered by SARS-CoV1 and Influenza viruses.
The treatment aims to suppress fluid accumulation, lung injury, and inflammation, which will in turn help to cut down the number of ICU patients and intubation/ventilation procedures.
According to the US Centers for Disease Control (CDC), 20 to 42% of hospitalized Covid-19 patients develop ARDS. Of this, 67 to 85% of patients get admitted to the ICU. Mortality rates are observed at 39 to 72% among those admitted to the ICU.
Phase II/III study will be adaptive, multicentre, randomized, double-blind, placebo-controlled, and will analyze the efficacy and safety of EB05 in hospitalized patients with or are at risk of ARDS.
During the trial, patients will be infused intravenously with a single dose of EB05 or placebo.
On obtaining promising results in the Phase II trial, Edesa plans to carry on with the Phase III trial.
Edesa CEO Dr. Par Nijhawan said: “Our EB05 study has been deemed safe to proceed by the FDA, marking another milestone in our plans to begin patient enrolment. We believe our drug candidate has the potential to inhibit a key proinflammatory pathway linked to some of the worst effects of the disease.”
Source: GlobalData.com
